Perchlorate (ClO4) and Perchlorate Salts

CASRN -98-9 | DTXSID

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• Key IRIS
  Values
• Other EPA
  Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (22 pp, 157 K) Last Updated: 02/18/

System RfD (mg/kg-day) Basis PoD Composite UF Confidence Endocrine 7 x 10 -4 Radioactive iodide uptake inhibition (RAIU) in the thyroid NOEL : 7 x 10-3
mg/kg-day 10 High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (22 pp, 157 K) Last Updated: 02/18/

Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (22 pp, 157 K) Last Updated: 02/18/

WOE Characterization Framework for WOE Characterization Not likely to be carcinogenic to humans Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, ) Basis:

• Under U.S. EPAs Draft Revised Guidelines for Carcinogen Risk Assessment, perchlorate is not likely to pose a risk of thyroid cancer in humans, at least at doses below those necessary to alter thyroid hormone homeostasis, based on the hormonally-mediated mode of action in rodent studies and species differences in thyroid function.
• This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (22 pp, 157 K)

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Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (22 pp, 157 K)

Not assessed under the IRIS Program.

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:

• Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
• Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
• Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

1S/ClHO4.H3N/c2-1(3,4)5;/h(H,2,3,4,5);1H3

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