4-(N-Boc-amino)phenylboronic Acid CAS 380430-49-9: Buyer’s Guide to Specifications, Applications, and Supply

4-(N-Boc-amino)phenylboronic acid, CAS 380430-49-9, is a protected aminophenyl boronic acid used primarily as a synthetic building block in medicinal chemistry, pharmaceutical intermediate development, and palladium-catalyzed cross-coupling research. The N-Boc group protects the amino functionality during synthesis, while the boronic acid group provides a reactive handle for transformations such as Suzuki–Miyaura coupling. For purchasing, I recommend confirming identity, assay, water content, residual solvents, packaging, and the intended project scale before comparing quotations. Maison Chemical can support specification review, documentation requests, and supply discussions for development or production-oriented requirements.

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Who This Buyer’s Guide Is For

This guide is intended for procurement professionals, process chemists, medicinal chemists, laboratory managers, and pharmaceutical intermediate buyers evaluating CAS 380430-49-9. It is also relevant to contract research organizations and chemical distributors that need a defined sourcing strategy rather than a simple spot quotation. The focus is on practical decisions: what to verify, how to match the material to an application, and how to reduce avoidable sourcing risk.

Because boronic acids can be sensitive to handling and storage conditions, buyers should avoid treating a catalogue name as a complete specification. A reliable purchasing decision should connect the chemical identity to the required reaction, scale, analytical method, and documentation package. When a project moves from screening to process development, the preferred specification may also become more demanding.

Basic Chemical Context

4-(N-Boc-amino)phenylboronic acid contains both a protected aniline functionality and an aryl boronic acid group. The Boc protecting group can help prevent undesired participation of the amino group during selected synthetic steps, while the boronic acid functionality is commonly used to introduce the substituted aromatic unit through cross-coupling chemistry. The compound is therefore valued for combining protection and reactivity in one intermediate.

Commonly reported reference information includes the molecular formula C₁₁H₁₆BNO₄ and a molecular weight of approximately 237.06 g/mol. Buyers should still verify these values against the supplier’s current specification and analytical documentation, particularly when the material may exist in different physical forms or when water content affects calculated assay. The product name, CAS number, formula, and analytical identity should be consistent across the quotation, label, specification, and certificate of analysis.

Specifications and Material Options

Identity and Purity

For routine research use, buyers commonly begin with appearance, identification, and assay or purity. Suitable identity evidence may include proton and carbon NMR, infrared data, mass spectrometry, and chromatographic information, depending on the supplier’s documentation package. Purity should be interpreted together with the analytical method because HPLC area percentage, assay by another method, and water-corrected content are not automatically equivalent.

A practical specification review should ask whether the reported result is a typical value or a release requirement. It should also clarify whether the product is supplied as a single defined material, whether it contains a stated amount of water or solvent, and whether the reported purity is corrected for such components. These details can affect reaction charging calculations and downstream reproducibility.

Physical Form, Packaging, and Stability

The commercial physical form should be confirmed before ordering because powders can differ in particle characteristics, flow behavior, and packaging requirements. A buyer should request the appearance description, recommended storage conditions, retest or review period if available, and packaging configuration. As a general precaution, boronic acid intermediates should be protected from unnecessary exposure to moisture, heat, and incompatible chemicals, while the supplier’s product-specific instructions should take priority.

Packaging should match the intended use. Small laboratory quantities may be appropriate for route scouting, whereas process development or commercial planning may require multiple containers, improved lot traceability, or a larger coordinated supply. I recommend confirming container size, net weight tolerance, labeling information, and whether samples can be drawn from the same production lot proposed for the larger order.

Application Matching

Medicinal Chemistry and Pharmaceutical Intermediate Research

CAS 380430-49-9 is commonly evaluated as an aryl boronic acid building block for preparing biaryl or heteroaryl-linked structures. In a Suzuki–Miyaura coupling, the boronic acid group can participate with a suitable aryl or heteroaryl halide under a compatible catalytic system. The protected amino group may be retained during coupling and removed later when the synthetic route requires an aniline functionality.

Actual performance depends on the reaction partners, catalyst, base, solvent, temperature, work-up, and purification method. I would not use a supplier’s general product description as a guarantee of yield or conversion for a particular substrate. Instead, buyers should assess the material through a small-scale compatibility experiment and retain the analytical records needed for route comparison.

Process Development and Scale-Up

For process work, the most important question is not only whether the compound reacts, but whether the material can be supplied consistently with controlled impurity and water profiles. Impurities that are acceptable during early discovery may become problematic if they carry through a coupling step or complicate isolation of the target intermediate. A process buyer should therefore discuss impurity information, lot-to-lot consistency, and change-notification expectations before approving a larger source.

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Buyer Selection Framework

Step 1: Define the Intended Use

Start by stating whether the material is required for analytical research, medicinal chemistry, route scouting, process development, or manufacturing support. The intended use determines the level of documentation, quantity, packaging, and lot control that may be necessary. It also helps the supplier recommend a realistic specification instead of quoting an unsuitable standard.

Step 2: Separate Mandatory and Preferred Requirements

Mandatory requirements may include CAS identity, a minimum purity, a specific packaging size, delivery to a defined location, or documentation in a specified format. Preferred requirements might include a narrower impurity profile, a particular analytical method, or a longer review period. Separating these categories makes quotation comparison more transparent and avoids paying for requirements that do not affect the application.

Step 3: Review Commercial Variables

Price should be assessed together with MOQ, available stock, production lead time, freight conditions, packaging, and documentation. A lower unit price may not be advantageous if the MOQ is too large, the lead time misses a campaign date, or the lot cannot support the required qualification work. Since current availability and pricing change by quantity and destination, I recommend requesting a project-specific quotation rather than relying on an old catalogue price.

For planning purposes, buyers should communicate the requested quantity in both grams and moles when practical. At the reference molecular weight of approximately 237.06 g/mol, a 100 g requirement represents roughly 0.422 mol before accounting for assay or water correction. This calculation helps the supplier understand the actual synthesis demand and helps the buyer check whether the quoted quantity is sufficient.

Supplier Evaluation Checklist

A qualified supplier should provide a clear product identity and a quotation that matches the requested CAS number. I recommend asking for a current specification, representative or lot-specific certificate of analysis, available analytical data, packaging details, storage guidance, and estimated lead time. If the supplier cannot clearly explain the basis of the purity result or the status of the offered lot, the buyer should pause qualification and request clarification.

Supply continuity is another important evaluation point. Ask whether the quoted material is in stock, produced to order, or dependent on an upstream source, and confirm whether the same specification can be maintained for repeat orders. For development programs, discuss sample-to-bulk alignment so that early reaction testing does not depend on a materially different lot from the one used later.

Maison Chemical supports B2B customers by reviewing technical requirements, discussing quantity and packaging needs, and coordinating product documentation for 4-(N-Boc-amino)phenylboronic acid CAS 380430-49-9. We can evaluate an inquiry according to application stage, target quantity, delivery destination, and documentation expectations. Availability, MOQ, lead time, and commercial terms should be confirmed for each specific request.

Common Purchasing Mistakes to Avoid

One common mistake is selecting only by the product name and CAS number without checking the analytical method or physical form. Another is assuming that a stated purity guarantees the same reaction outcome across different substrates and process conditions. Buyers should also avoid ordering a large quantity before confirming that the material performs acceptably in the intended transformation.

A further risk is neglecting storage and handling information after delivery. The receiving team should check the label, container integrity, lot number, and certificate against the purchase order, then store the product according to the supplier’s instructions. Any discrepancy should be documented and raised before the material enters a critical synthetic campaign.

Key Takeaways

• 4-(N-Boc-amino)phenylboronic acid CAS 380430-49-9 is a protected aminophenyl boronic acid building block used in synthetic and pharmaceutical intermediate research.
• Confirm identity, assay method, impurity information, moisture or solvent content, physical form, packaging, and storage conditions before purchase.
• Match the specification to the project stage: discovery, route scouting, process development, or larger-scale supply.
• Compare total sourcing value, including MOQ, lead time, documentation, lot continuity, and logistics—not unit price alone.
• Request a current quotation and product documentation from Maison Chemical before making a purchase decision.

Conclusion and Next Steps

The best way to buy 4-(N-Boc-amino)phenylboronic acid CAS 380430-49-9 is to treat it as a project-specific pharmaceutical intermediate rather than a generic catalogue chemical. Confirm the chemical identity and analytical basis first, then match purity, packaging, quantity, and supply timing to the intended reaction and development stage. This approach provides a more reliable basis for technical qualification and commercial comparison.

To begin, prepare your required quantity, target purity, application stage, delivery location, packaging preference, and documentation needs. Send these details to Maison Chemical for a current supply assessment, quotation, and technical discussion. We will help you clarify the available specification and determine the most practical next step for your procurement plan.

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