2,4-Difluorophenylboronic Acid CAS 144025-03-6: A Buyer’s Guide to Properties, Uses, and Supply

2,4-Difluorophenylboronic acid, CAS 144025-03-6, is an organoboron building block used primarily to introduce a 2,4-difluorophenyl group into more complex molecules. Its principal value is in palladium-catalyzed Suzuki–Miyaura cross-coupling, where the boronic acid functionality reacts with suitable aryl or heteroaryl halides to form carbon–carbon bonds. The compound is commonly identified by the molecular formula C₆H₅BF₂O₂ and an approximate molecular weight of 157.92 g/mol. At Maison Chemical, we support buyers with product identification, specification review, quotation, packaging coordination, and export-oriented supply planning.

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Who This Guide Is For

This guide is intended for medicinal chemistry teams, pharmaceutical research organizations, agrochemical developers, custom synthesis companies, and procurement specialists sourcing small quantities or production-support quantities of 2,4-Difluorophenylboronic acid. It is also useful for buyers comparing suppliers of fluorinated arylboronic acids. Because commercial requirements vary by project, the correct purchasing decision should consider more than the CAS number alone.

Researchers usually need reliable identity and usable coupling performance, while procurement teams may focus on lot consistency, packaging, documentation, lead time, and total landed cost. A suitable supplier should therefore provide clear product information before an order is placed. Where a requirement is not defined in the buyer’s specification, I recommend confirming it rather than assuming that all commercially available material is equivalent.

Basic Concept and Chemical Identity

What Is 2,4-Difluorophenylboronic Acid?

2,4-Difluorophenylboronic acid is an arylboronic acid containing a phenyl ring substituted with fluorine atoms at the 2- and 4-positions, together with a boronic acid group. The boronic acid group is chemically useful because it can participate in cross-coupling reactions under appropriately selected conditions. The two fluorine substituents can influence the electronic and lipophilic properties of the resulting molecule, which is one reason this building block is considered in discovery chemistry.

The product should not be confused with other fluorinated phenylboronic acids, such as 2-fluoro-, 3-fluoro-, or 4-fluorophenylboronic acid. Positional isomers can have different reactivity, purification behavior, and downstream biological or physical properties. For this reason, I recommend verifying the product name, CAS number, molecular formula, and structure before approving a purchase.

Key Product Information

Uses and Application Matching

Suzuki–Miyaura Cross-Coupling

The most established use of this material is as a coupling partner in Suzuki–Miyaura chemistry. In a typical research workflow, the arylboronic acid is combined with an aryl, heteroaryl, or vinyl halide in the presence of a suitable palladium catalyst, base, solvent, and reaction protocol. The actual outcome depends on the halide, catalyst system, substrate sensitivity, water content, temperature, and work-up method, so I do not recommend treating the building block as a guarantee of a particular conversion or yield.

The product is especially relevant when a synthesis requires a difluorinated aromatic fragment. Fluorine substitution may be used by medicinal chemists to adjust molecular properties, but the final effect depends on the complete molecular structure. In practice, this compound may be selected during analogue synthesis, structure–activity relationship studies, lead optimization, or route exploration.

Medicinal and Agrochemical Research

Fluorinated arylboronic acids are frequently evaluated as intermediates in research programs involving pharmaceutical, biochemical, and agrochemical molecules. 2,4-Difluorophenylboronic acid can provide a convenient route to biaryl or heteroaryl-aryl structures when the target design includes the corresponding substitution pattern. It may also be used in custom synthesis and reference-compound preparation, subject to the requirements of the specific project.

Buyers should distinguish between a building block and a regulated finished product. This material is a research and manufacturing intermediate, not a finished pharmaceutical ingredient, pesticide formulation, or validated therapeutic substance. Any downstream regulatory status must be assessed for the final molecule and intended market rather than inferred from this raw material alone.

Material Options and Specification Considerations

What to Confirm Before Ordering

The first requirement is chemical identity: confirm the exact CAS number, structure, formula, and intended positional isomer. The second is quality level, which may be expressed as an assay target or supported by analytical documentation such as chromatographic data, nuclear magnetic resonance data, or mass spectrometric information. The appropriate acceptance criteria depend on whether the material is intended for route scouting, medicinal chemistry, process development, or a more demanding manufacturing stage.

Moisture and storage history may also matter because boronic acids can be sensitive to handling and storage conditions. Buyers should ask how the material is packaged, whether the container is suitable for the expected storage period, and what storage guidance is supplied. Where a project requires a defined impurity profile, I recommend requesting a specification discussion before purchase rather than relying only on a catalogue description.

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• Identity: CAS 144025-03-6 and matching chemical structure.
• Assay or purity requirement: defined according to the application.
• Impurity profile: especially important for process and scale-up work.
• Water or residual solvent expectations: confirm when reaction performance is sensitive.
• Packaging: select a format compatible with laboratory, pilot, or production use.
• Documentation: request the available batch and shipping documents before approval.

Buyer Selection Framework

Step 1: Define the Intended Use

Start by identifying the reaction stage and the quantity required. A small discovery experiment may need only a laboratory pack, while process development may require repeated lots with tighter documentation and supply continuity. The intended use determines how much emphasis should be placed on price, analytical detail, batch history, and change-control communication.

Step 2: Match the Specification to the Risk

For early screening, a commercially available research grade may be sufficient if the identity and quality are clear. For scale-up, the buyer should examine lot-to-lot consistency, impurity limits, packaging, and the supplier’s ability to discuss future production requirements. I recommend requesting a current specification and representative documentation rather than comparing suppliers solely by listed purity.

Step 3: Evaluate Supply Practicalities

Price is only one part of the purchase decision. Minimum order quantity, production status, available stock, lead time, export documents, shipping conditions, and the possibility of repeat orders can materially affect project cost. Because these factors change by quantity, destination, and timing, Maison Chemical provides quotations based on the buyer’s specific requirement instead of presenting an unsupported universal price or lead-time promise.

Step 4: Confirm Safe Handling and Storage

Handling should follow the current safety data sheet, internal laboratory procedures, and applicable local requirements. Personnel should review hazard communication, personal protective equipment, ventilation, spill response, and waste disposal procedures before use. Storage conditions should be confirmed from the supplied documentation, particularly when the material will be held for an extended period or transported internationally.

Common Purchasing Mistakes

One common mistake is ordering a fluorinated phenylboronic acid by a shortened name without checking the substitution pattern. Another is assuming that a high assay value alone proves suitability for every coupling system; reaction performance can also be affected by water, particle characteristics, impurities, and the reaction design. A third mistake is waiting until the final procurement stage to discuss packaging, documentation, or repeat-supply needs.

Buyers should also avoid treating catalogue availability as confirmation of immediate shipment. Availability can depend on lot status, quality release, order quantity, and destination requirements. A written quotation that identifies the product, quantity, specification basis, packaging, and delivery assumptions is a more reliable foundation for purchasing decisions.

How Maison Chemical Supports Buyers

At Maison Chemical, I approach 2,4-Difluorophenylboronic acid as a technical sourcing requirement rather than a simple catalogue transaction. We can review the requested CAS number and application, clarify the desired quality level, coordinate packaging options, and prepare a quotation for the required quantity. For international buyers, we can also discuss export documentation and delivery requirements during the inquiry process.

Our support is designed for both research purchasing and longer-term supply evaluation. If the project involves route development or repeat consumption, I recommend sharing the estimated annual demand, preferred pack size, target delivery region, and documentation expectations. This information allows us to assess the most practical supply approach without making claims that cannot be confirmed for a particular order.

Key Takeaways

• 2,4-Difluorophenylboronic acid is a fluorinated arylboronic acid identified by CAS 144025-03-6.
• Its main role is as a building block for Suzuki–Miyaura and related carbon–carbon bond-forming research.
• The stated molecular formula is C₆H₅BF₂O₂, with an approximate molecular weight of 157.92 g/mol.
• Buyers should verify identity, quality requirements, moisture expectations, packaging, documentation, and supply timing.
• Supplier selection should reflect the project stage, from early discovery to process development and repeat procurement.

Conclusion: Is This the Right Building Block for Your Project?

2,4-Difluorophenylboronic acid CAS 144025-03-6 is a suitable candidate when your synthesis requires a 2,4-difluorinated aryl fragment and a boronic acid coupling handle. Its usefulness is strongest in medicinal chemistry, custom synthesis, and related research where controlled carbon–carbon bond formation is needed. The final choice should be based on verified identity, application-specific specifications, handling requirements, and dependable supply planning.

As your next step, prepare the required quantity, target specification, pack size, destination, and documentation needs, then send these details to Maison Chemical for review. We can help determine the appropriate supply format and provide a project-specific quotation. Contact Maison Chemical to discuss 2,4-Difluorophenylboronic acid for your next synthesis or procurement program.

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